A new preparation of modified immune serum globulin (human) suitable for intravenous administration. II. Functional characterization

Autor:	D D, Schroeder, D L, Tankersley, J L, Lundblad
Rok vydání:	1981
Předmět:	Vasomotor System Epitopes Immune Sera Guinea Pigs Animals Humans Infusions Parenteral Complement System Proteins Rabbits Injections Intramuscular
Zdroj:	Vox sanguinis. 40(6)
ISSN:	0042-9007
Popis:	The commercial immune serum globulin (ISG) product is suitable for use in passive immunization only by intramuscular administration; intravenous use results in vasomotor side reactions. We report the functional characterization of a chemically modified ISG (MISG) that is essentially free of nonspecific complement-binding activity and contains no new antigenic determinants. The half-life values for MISG given intravenously to rabbits, guinea pigs, and humans are shown not to be different from that of ISG. The MISG we describe is shown to fulfill the in vitro and in vivo criteria of stability, safety, function, and half-life, making it suitable for human intravenous administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3e141b78989586d120040f94ac24a169 https://pubmed.ncbi.nlm.nih.gov/6170170 Zobrazit plný text záznamu Plný text