Monitoring acute inflammatory processes in mouse muscle by MR imaging and spectroscopy: a comparison with pathological results

Autor:	Jesús, Ruiz-Cabello, Javier, Regadera, Carmen, Santisteban, Manuel, Graña, Rigoberto, Pérez de Alejo, Imanol, Echave, Pablo, Avilés, Ignacio, Rodriguez, Inmaculada, Santos, Domingo, Gargallo, Manuel, Cortijo
Rok vydání:	2002
Předmět:	Male Magnetic Resonance Spectroscopy Myositis Aspergillus fumigatus Phosphorus Magnetic Resonance Imaging Mice Mycoses Thigh Acute Disease Image Interpretation Computer-Assisted Disease Progression Animals Nerve Net
Zdroj:	NMR in biomedicine. 15(3)
ISSN:	0952-3480
Popis:	We have studied an animal model of acute local inflammation in muscle induced by Aspergillus fumigatus by using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). We have compared our data to those found using histopathology and segmentation maps obtained by the mathematical processing of three-dimensional T2-weighted MRI data via a neural network. The MRI patterns agreed satisfactorily with the clinical and biological evidence of the phases of acute local infection and its evolution towards chronicity. The MRS results show a statistically significant increase in inorganic phosphate and a significant decrease in phosphocreatine levels in the inflamed region. Image segmentation made with a self-organizing, neural-network map yielded a set of ordered representatives that remained constant for all animals during the inflammatory process, allowing a non-invasive, three-dimensional identification and quantification of the inflamed infected regions by MRI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3db813b1c6128d38b04dba05eee9baa0 https://pubmed.ncbi.nlm.nih.gov/11968136 Zobrazit plný text záznamu Plný text