| Autor: |
S, Zubchenko, A, Havrylyuk, M, Lomikovska, I, Kril, S, Chuiko |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Georgian medical news. (328-329) |
| ISSN: |
1512-0112 |
| Popis: |
Beta-lactam antibiotics (BLAs) can provoke drug hypersensitivity reactions, particularly delayed-type reactions. This article presents a case of drug allergy with manifestations of Stevens-Johnson syndrome (SJD) in a 42-year-old man with yersiniosis and active herpesvirus -4, -6 type, who received amoxacillin with clavulanic acid. The patient underwent a basophil activation test (BAT) for BLAs, and a positive result was found for both amoxacillin and 2nd and 3rd generation cephalosporins. On the example of a clinical case, probable pathogenetic mechanisms of the risk of the appearance of immediate-type hypersensitivity reactions in persons with active herpesvirus -4, -6 type infection are shown. The possibility of using the cellular BAT for the diagnosis of delayed-type hypersensitivity reactions and for the diagnosis of cross-reactions to antibiotics has also been demonstrated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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