Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum

Autor:	T A, Voronina, G G, Borlikova, T L, Garibova, T V, Proskuryakova, O B, Petrichenko, S G, Burd, G N, Avakyan
Rok vydání:	2003
Předmět:	Male Diazepam Receptors Dopamine D2 Nicotinic Acids In Vitro Techniques Corpus Striatum Rats Substance Withdrawal Syndrome Kinetics Anti-Anxiety Agents Glutamates Spiperone Animals Receptors AMPA Nootropic Agents
Zdroj:	Bulletin of experimental biology and medicine. 134(5)
ISSN:	0007-4888
Popis:	A new nootropic preparation nooglutil (N-(5-oxynicotinoyl)-L-glutamic acid), a positive modulator of AMPA receptors for glutamate, administered intraperitoneally in a dose of 70 mg/kg reduced anxiety of rats in the Vogel conflict test after 24-h withdrawal from chronic diazepam treatment (4 mg/kg intraperitoneally for 45 days). Nooglutil (5 nM-750 microM) had no effect on in vitro binding of (3)H-spiperone in intact rats. Systemic administration of 50 mg/kg nooglutil in vivo increased the dissociation constant and density of D(2)receptors. Increasing the dose to 100 mg/kg abolished this effect. Our findings suggest that nooglutil produces an indirect effect on the brain dopaminergic system under normal and pathological conditions and this effect is probably mediated via the glutamatergic system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3d6ae305bcc2cd0088194179b16459e5 https://pubmed.ncbi.nlm.nih.gov/12802448 Zobrazit plný text záznamu Full text from SpringerLink