Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1
| Autor: | M N, Oxman, A S, Levine, C S, Crumpacker, M J, Levin, P H, Henry, A M, Lewis |
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| Rok vydání: | 1971 |
| Předmět: |
DNA Replication
Genetics Microbial Carbon Isotopes Virus Cultivation Base Sequence viruses Nucleic Acid Hybridization Haplorhini Simian virus 40 biochemical phenomena metabolism and nutrition Kidney Adenoviridae Cell Line stomatognathic diseases Genetic Code Culture Techniques DNA Viral Animal Viruses Animals Humans Hybridization Genetic RNA Viral Antigens Viral Thymidine |
| Zdroj: | Journal of virology. 8(2) |
| ISSN: | 0022-538X |
| Popis: | Ad2(+)ND(1), a nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, has been previously shown to contain a small segment of the SV40 genome covalently linked to Ad2 deoxyribonucleic acid (DNA). The SV40 portion of this hybrid virus has been characterized by relating the SV40-specific ribonucleic acid (RNA) sequences transcribed from the Ad2(+)ND(1) DNA to those transcribed from the DNA of SV40 itself. RNA-DNA hybridization-competition studies indicate that the SV40 component of Ad2(+)ND(1) consists of some, but not all, of that part of the SV40 genome which is transcribed early, i.e., prior to viral DNA replication, in SV40 lytic infection. |
| Databáze: | OpenAIRE |
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