Changes in PINCH and hpTau levels in the CSF of HIV patients correlate with CD4 count
| Autor: | Adiga, Radhika, Ozdemir, Ahmet Y., Carides, Alexandra, Wasilewski, Melissa, Yen, William, Chitturi, Pallavi, Ellis, Ronald, Langford, Dianne |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Blotting Western Membrane Proteins Enzyme-Linked Immunosorbent Assay HIV Infections tau Proteins LIM Domain Proteins Middle Aged Article CD4 Lymphocyte Count body regions Anti-Retroviral Agents Humans Drug Therapy Combination Female sense organs Phosphorylation Adaptor Proteins Signal Transducing |
| Popis: | Several studies report associations between the PINCH (particularly interesting new cysteine histidine-rich) protein and HIV-associated CNS disease. PINCH is detected in the CSF of HIV patients and changes in levels during disease may be indicative of changes in disease status over time. PINCH binds hyperphosphorylated Tau (hpTau) in the brain and CSF, but little is known about the relevance of these interactions to HIV CNS disease. In this study, PINCH and hpTau levels were assessed in three separate CSF samples collected longitudinally from 20 HIV+ participants before and after initiating antiretroviral therapy, or before and after a change in the current regimen. The intervals were approximately 1 (T2), and 3-7 (T3) months from the initial visit (baseline, T1). Correlational analyses were conducted for CSF levels of PINCH and hpTau and other variables including blood CD4+ T-cell count, plasma and CSF viral burden, CSF neopterin, white blood cell (WBC) count, and antiretroviral CNS penetration-effectiveness (CPE). Values for PINCH and hpTau were determined for each patient by calculating the fold changes between the second (T2) and third measurements (T3) from the baseline measurement (T1). Statistical analyses showed that the fold-change in CSF PINCH protein from T1 to T2 were significantly higher in participants with CD4 counts >200 cells/mm3 at T2 compared to those with CD4 counts |
| Databáze: | OpenAIRE |
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