A combination of plaque components analyzed by integrated backscatter intravascular ultrasound and serum pregnancy-associated plasma protein a levels predict the no-reflow phenomenon during percutaneous coronary intervention
| Autor: | Hyuma, Daidoji, Hiroki, Takahashi, Yoichiro, Otaki, Harutoshi, Tamura, Takanori, Arimoto, Tetsuro, Shishido, Takehiko, Miyashita, Takuya, Miyamoto, Tetsu, Watanabe, Isao, Kubota |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Coronary Artery Disease Middle Aged Coronary Vessels Plaque Atherosclerotic Logistic Models Percutaneous Coronary Intervention Treatment Outcome ROC Curve Predictive Value of Tests Risk Factors Area Under Curve Coronary Circulation Multivariate Analysis Humans No-Reflow Phenomenon Pregnancy-Associated Plasma Protein-A Female Prospective Studies Biomarkers Ultrasonography Interventional Aged Proportional Hazards Models |
| Zdroj: | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions. 85(1) |
| ISSN: | 1522-726X |
| Popis: | Previous studies reported that integrated backscatter intravascular ultrasound (IB-IVUS) provides high diagnostic accuracy for tissue characterization of coronary plaques and that pregnancy-associated plasma protein A (PAPP-A) could be a marker of adverse cardiac outcome in patients with cardiovascular disease. We examined whether IB-IVUS and PAPP-A levels could predict the incidence of no-reflow during percutaneous coronary intervention (PCI) METHODS AND RESULTS: About 176 consecutive patients (138 men, mean age 68 ± 11 years) who underwent PCI with IB-IVUS were prospectively enrolled. Combined no-reflow, including transient filter no-reflow by using distal protection devices, was observed in 31 patients. The percentages of coronary lipid volume (%LV) analyzed by IB-IVUS and serum PAPP-A were significantly higher in patients with combined no-reflow than normal-reflow. To predict no-reflow, a receiver operating characteristic (ROC) analysis determined cut-off values of %LV as 62% and serum PAPP-A as 7.71 ng/mL. The multivariate logistic regression analysis showed that %LV (hazard ratio 4.5, 95% confidence interval 1.6-13.4, P 0.01) and PAPP-A (hazard ratio 4.32, 95% confidence interval 1.5-12.7, P 0.01) were independent predictors of combined no-reflow%LV analyzed by IB-IVUS and serum PAPP-A levels were closely associated with the coronary no-reflow phenomenon. © 2014 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text