Association between promoter region genetic variants of PTH SNPs and serum 25(OH)-vitamin D level
| Autor: | Al-Daghri, Nasser M, Al-Attas, Omar S, Krishnaswamy, Soundararajan, Yakout, Sobhy M, Mohammed, Abdul Khader, Alenad, Amal M, Chrousos, George P, Alokail, Majed S |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Saudi Arabia Middle Aged Vitamin D Deficiency Polymorphism Single Nucleotide Young Adult Cross-Sectional Studies Phenotype Gene Frequency Parathyroid Hormone Risk Factors Ethnicity Prevalence Humans Original Article Female Genetic Predisposition to Disease Vitamin D Promoter Regions Genetic |
| Popis: | Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level. Besides, hypersecretion of PTH is implicated in the etiology of osteoporosis. In this study, we analyzed association between promoter region sequence variants of PTH gene and circulating 25-hydroxy-vitamin D (25(OH)D) level. Genotypes of PTH SNPs rs1459015, rs10500783 and rs10500784 and circulating serum 25(OH)D level of healthy adults (N=386) of different nationalities living in Riyadh were determined and relation between the different PTH allelic variants and corresponding mean 25(OH)D values were obtained using Analysis of Variance (ANOVA) and Bonferroni post-hoc test for multiple comparisons. We observed a high prevalence of vitamin D deficiency ( |
| Databáze: | OpenAIRE |
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