pH-sensitive packaging of cationic particles by an anionic block copolymer shell

Autor:	Jana I, Solomun, Liam, Martin, Prosper, Mapfumo, Elisabeth, Moek, Elias, Amro, Friedrich, Becker, Stefan, Tuempel, Stephanie, Hoeppener, K Lenhard, Rudolph, Anja, Traeger
Rok vydání:	2021
Předmět:	Mice HEK293 Cells Polymers Cations Animals Humans Hydrogen-Ion Concentration Transfection Polyethylene Glycols
Zdroj:	Journal of nanobiotechnology. 20(1)
ISSN:	1477-3155
Popis:	Cationic non-viral vectors show great potential to introduce genetic material into cells, due to their ability to transport large amounts of genetic material and their high synthetic versatility. However, designing materials that are effective without showing toxic effects or undergoing non-specific interactions when applied systemically remains a challenge. The introduction of shielding polymers such as polyethylene glycol (PEG) can enhance biocompatibility and circulation time, however, often impairs transfection efficiency. Herein, a multicomponent polymer system is introduced, based on cationic and hydrophobic particles (P(nBMA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3d2316c8b9dc9833b86c2eb89a890e6f https://pubmed.ncbi.nlm.nih.gov/35842657 Zobrazit plný text záznamu Full text from SpringerLink