| Autor: |
Alexandra F, Dalton, Zachary A, Weber, Katie S, Allen, Edward, Stenehjem, Stephanie A, Irving, Talia L, Spark, Katherine, Adams, Ousseny, Zerbo, Victoria, Lazariu, Brian E, Dixon, Kristin, Dascomb, Emily, Hartmann, Anupam B, Kharbanda, Toan C, Ong, Malini B, DeSilva, Maura, Beaton, Manjusha, Gaglani, Palak, Patel, Allison L, Naleway, Magdalene N, Sam Kish, Shaun J, Grannis, Nancy, Grisel, Chantel, Sloan-Aagard, Suchitra, Rao, Chandni, Raiyani, Monica, Dickerson, Elizabeth, Bassett, William F, Fadel, Julie, Arndorfer, Juan, Nanez, Michelle A, Barron, Gabriela, Vazquez-Benitez, I-Chia, Liao, Eric P, Griggs, Sarah E, Reese, Nimish R, Valvi, Kempapura, Murthy, Elizabeth A K, Rowley, Peter J, Embi, Sarah, Ball, Ruth, Link-Gelles, Mark W, Tenforde |
| Rok vydání: |
2022 |
| Zdroj: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. |
| ISSN: |
1537-6591 |
| Popis: |
COVID-19 vaccination coverage remains lower in communities with higher social vulnerability. Factors such as SARS-CoV-2 exposure risk and access to health care are often correlated with social vulnerability and may therefore contribute to a relationship between vulnerability and observed vaccine effectiveness (VE). Understanding whether these factors impact VE could contribute to our understanding of real-world VE.We used electronic health record data from seven health systems to assess vaccination coverage among patients with medically attended COVID-19-like illness. We then used a test-negative design to assess VE for 2- and 3-dose mRNA adult (≥18 years) vaccine recipients across Social Vulnerability Index (SVI) quartiles. SVI rankings were determined by geocoding patient addresses to census tracts; rankings were grouped into quartiles for analysis.In July 2021, primary series vaccination coverage was higher in the least vulnerable quartile than in the most vulnerable quartile (56% vs. 36%, respectively). In February 2022, booster dose coverage among persons who had completed a primary series was higher in the least vulnerable quartile than in the most vulnerable quartile (43% vs. 30%). VE among 2-dose and 3-dose recipients during the Delta and Omicron BA.1 periods of predominance was similar across SVI quartiles.COVID-19 vaccination coverage varied substantially by SVI. Differences in VE estimates by SVI were minimal across groups after adjusting for baseline patient factors. However, lower vaccination coverage among more socially vulnerable groups means that the burden of illness is still disproportionately borne by the most socially vulnerable populations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
