HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium
| Autor: | T, Mrowiec, C, Melchar, A, Górski |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Extracellular Matrix Proteins
Membrane Glycoproteins T-Lymphocytes Vascular Cell Adhesion Molecule-1 HIV Envelope Protein gp120 Intercellular Adhesion Molecule-1 Lymphocyte Activation Gene Products nef Gene Products tat Cell Adhesion HIV-1 Humans tat Gene Products Human Immunodeficiency Virus Endothelium Vascular nef Gene Products Human Immunodeficiency Virus E-Selectin Cell Adhesion Molecules Cells Cultured |
| Zdroj: | Archivum immunologiae et therapiae experimentalis. 45(2-3) |
| ISSN: | 0004-069X |
| Popis: | Recent data point to the immunoregulatory role of extracellular matrix (ECM) proteins in the process of T cell activation. We studied the effects of HIV proteins on those interactions as well as on endothelial adhesion molecule expression. Gp 120 and gp 41 inhibited CD3-triggered T cell co-stimulation by the ECM proteins, while Nef was stimulatory. T cell adhesion to the ECM proteins was affected in a similar fashion. Furthermore, tat induced E-selectin (but not VCAM-1 and ICAM-1) endothelial expression. Those findings may be relevant for the understanding of immunopathology of AIDS. |
| Databáze: | OpenAIRE |
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