Mucosal or systemic microbiota exposures shape the B cell repertoire
| Autor: | Hai, Li, Julien P, Limenitakis, Victor, Greiff, Bahtiyar, Yilmaz, Olivier, Schären, Camilla, Urbaniak, Mirjam, Zünd, Melissa A E, Lawson, Ian D, Young, Sandra, Rupp, Mathias, Heikenwälder, Kathy D, McCoy, Siegfried, Hapfelmeier, Stephanie C, Ganal-Vonarburg, Andrew J, Macpherson |
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| Rok vydání: | 2019 |
| Předmět: |
Male
B-Lymphocytes Clostridiales Plasma Cells Administration Oral Immunoglobulin A Mice Inbred C57BL Mice Immunoglobulin G Repetition Priming Escherichia coli Animals Germ-Free Life Administration Intravenous Female Intestinal Mucosa Immunoglobulin Heavy Chains Symbiosis Immunity Mucosal Immunologic Memory |
| Zdroj: | Nature. 584(7820) |
| ISSN: | 1476-4687 |
| Popis: | Colonization by the microbiota causes a marked stimulation of B cells and induction of immunoglobulin, but mammals colonized with many taxa have highly complex and individualized immunoglobulin repertoires |
| Databáze: | OpenAIRE |
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