Ambrisentan for sarcoidosis associated pulmonary hypertension
| Autor: | M A, Judson, K B, Highland, S, Kwon, J F, Donohue, R, Aris, N, Craft, S, Burt, H J, Ford |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Exercise Tolerance Time Factors Phenylpropionates Sarcoidosis Hypertension Pulmonary South Carolina Recovery of Function Middle Aged Respiratory Function Tests Pyridazines Treatment Outcome Surveys and Questionnaires Exercise Test North Carolina Quality of Life Humans Female Prospective Studies Lung Antihypertensive Agents |
| Zdroj: | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 28(2) |
| ISSN: | 1124-0490 |
| Popis: | Sarcoidosis associated pulmonary hypertension (SAPH) is associated with significant morbidity and mortality. There is a paucity of information concerning therapy for this condition.We performed a prospective, open-label, proof of concept trial of ambrisentan for SAPH. 21 subjects with SAPH received 5 mg/day of ambrisentan for 4 weeks and then 10/mg day for 20 subsequent weeks.No significant change was noted in the 6-minute walk distance over the course of the study (mean change between week 0 and 24: 9.8 +/- 54.6 meters, p: NS). There were also no significant differences between weeks 0 and 24 in terms of dyspnea as measured by the modified Borg scale, serum brain naturetic peptide, diffusing capacity, and quality of life as measured by the Short Form-36. There was a high dropout rate: overall: 11/21, 52%; social reasons: 3/21, 14%; medical reasons: 8/21, 38% because of dyspnea: 6/21, 29% and/or edema: 4/21, 19%. Of those who completed the 24 week study (10/21, 48%), there was an improvement in their WHO functional class and a marked improvement in their health related quality of life as measured by the St. George Respiratory questionnaire (-15.3 +/- 25.0). However both these improvments did not reach statistical significance possibly because of the small sample size.Although ambrisentan was not well tolerated by many of these subjects with SAPH, in those who remained in this 24-week trial, improvements in WHO functional class and in health related quality of life suggested a possible benefit of this drug in selected patients. |
| Databáze: | OpenAIRE |
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