The KIR and CD94/NKG2 families of molecules in the rhesus monkey
| Autor: | M L, LaBonte, K L, Hershberger, B, Korber, N L, Letvin |
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| Rok vydání: | 2002 |
| Předmět: |
Membrane Glycoproteins
Membrane Proteins Macaca mulatta Receptors KIR Antigens CD Animals Humans Receptors Natural Killer Cell Lectins C-Type Amino Acid Sequence Receptors Immunologic NK Cell Lectin-Like Receptor Subfamily C NK Cell Lectin-Like Receptor Subfamily D Sequence Alignment Conserved Sequence Phylogeny |
| Zdroj: | Immunological reviews. 183 |
| ISSN: | 0105-2896 |
| Popis: | Natural killer (NK) cells and a subset of T cells express families of receptors that are capable of detecting major histocompatibility complex (MHC) class I expression on the surface of cells. Molecules of the killer cell immunoglobulin-like receptor (KIR) family bind directly to MHC class I, while those of the CD94/NKG2 family recognize MHC class I signal sequences bound to HLA-E. Both the KIR and CD94/NKG2 families are composed of activating and inhibitory molecules that serve to regulate the function of NK cells as a result of their MHC class I recognition. Here we review the recently described KIR and CD94/NKG2 family members in the rhesus monkey. |
| Databáze: | OpenAIRE |
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