| Autor: |
Laura Raniere Borges, Dos Anjos, Adeliane Castro, da Costa, Amanda da Rocha Oliveira, Cardoso, Rafael Alves, Guimarães, Roberta Luiza, Rodrigues, Kaio Mota, Ribeiro, Kellen Christina Malheiros, Borges, Ana Carolina de Oliveira, Carvalho, Carla Iré Schnier, Dias, Aline de Oliveira, Rezende, Carine de Castro, Souza, Renato Rodney Mota, Ferreira, Guylherme, Saraiva, Lilia Cristina de Souza, Barbosa, Tayro da Silva, Vieira, Marcus Barreto, Conte, Marcelo Fouad, Rabahi, André, Kipnis, Ana Paula, Junqueira-Kipnis |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in immunology. 13 |
| ISSN: |
1664-3224 |
| Popis: |
The Bacillus Calmette-Guérin (BCG) vaccine, which is widely used to protect children against tuberculosis, can also improve immune response against viral infections. This unicentric, randomized-controlled clinical trial assessed the efficacy and safety of revaccination with BCG Moscow in reducing the positivity and symptoms of COVID-19 in health care workers (HCWs) during the COVID-19 pandemic. HCWs who had negative COVID-19 IgM and IgG and who dedicated at least eight hours per week in facilities that attended to individuals suspected of having COVID-19 were included in the study and were followed for 7, 15, 30, 60, and 180 days by telemedicine. The HCWs were randomly allocated to a revaccinated with BCG group, which received the BCG vaccine, or an unvaccinated group. Revaccination with BCG Moscow was found to be safe, and its efficacy ranged from 30.0% (95.0%CI -78.0 to 72.0%) to 31.0% (95.0%CI -74.0 to 74.0%). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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