| Autor: |
M, Akagi, K, Hamada, E, Nishioka, N, Fukuishi, R, Akagi |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Methods and findings in experimental and clinical pharmacology. 17 |
| ISSN: |
0379-0355 |
| Popis: |
Hypoxia elicited a remarkable decrease in contractility and heart rate in isolated right atria from guinea pigs, a decrease which recovered partially during reoxygenation. Histamine content increased during hypoxia and decreased during reoxygenation. However, hypoxia induced a marked degranulation of mast cells. Pretreatment with alpha-methylhistamine (100-300 nM) recuperated control level contractility and heart rate, and prevented the hypoxia-reoxygenation-induced leakage of creatine phosphokinase (CPK). On the other hand, pretreatment with thioperamide (100-300 nM) decreased contractility and heart rate dose-dependently, and prevented recovery during reoxygenation. These data shows that cardiac histamine may play an important role in the protection against hypoxia-reoxygenation injury through the H3 receptor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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