| Autor: |
N, Neykova, D, Simov, G, Galunska, E, Velichkova, A S, Galabov, A, Karparov |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 31(5) |
| ISSN: |
0004-4172 |
| Popis: |
benzoxazolone-5-(2'-nitro)-sulphonanilides were synthesized by acylation of o-nitroanilines with benzoxazolone-5-sulphochloride or 3-methylbenzoxazolone-5-sulphochloride. The nitro group in these compounds was subjected to reduction and the resulting amino derivatives were cyclysed to yield the corresponding 1-(benzoxazolone-5'-sulphonyl)-benzotriazoles. Decyclization of the oxazolone cycle of benzoxazolone-5-(2'-amino)-sulphonanilides resulted in 4-hydroxy-3,2'-diaminobenzenesulphonanilides. In vitro testing of the antiviral activity of the compounds obtained during successive synthetic steps revealed that some of them exhibited marked antiviral effect against toga, orthomixo, oncorna and herpes viruses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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