| Autor: |
I, Varga, G, Sóczó, G, Kardos, A, Kemény-Beke, B, Kelentey, I, Márton, L, Majoros |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Journal of chemotherapy (Florence, Italy). 21(1) |
| ISSN: |
1973-9478 |
| Popis: |
Minimum fungicidal concentration (mFC) of caspofungin was determined against 16 Candida albicans and 16 C. krusei in Rpmi-1640 and antibiotic medium 3 (Am3). time-kill tests were performed on six C. albicans and four C. krusei strains at 0.06-16 mg/l caspofungin. mFC ranges after 48 h were 0.5-1 and 1-2 mg/l for C. albicans and C. krusei, respectively; one C. albicans and the C. krusei reference strain showed paradoxical growth (pG) in Rpmi-1640, respectively. in killing experiments, after 48 h caspofugin was fungicidal against two and four C. albicans in Rpmi-1640 (at 16 mg/l) and in Am3 (at0.5 mg/l), respectively; pG was noted in three and two cases, respectively. Caspofungin at2 and 0.5 mg/l was fungicidal against all tested C. krusei strains even after 24 h in Rpmi-1640 and Am3, respectively. Killing activity of caspofungin against C. albicans and C. krusei could be exactly measured only by killing curves. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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