[Synthesis and pharmacological activity of betulin dinicotinate]
| Autor: | O B, Flekhter, L T, Karachurina, L R, Nigmatullina, T A, Sapozhnikova, L A, Baltina, F S, Zarudiĭ, F Z, Galin, L V, Spirikhin, G A, Tolstikov, O A, Pliasunova |
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| Rok vydání: | 2003 |
| Předmět: |
Dose-Response Relationship
Drug Anti-HIV Agents Cell Survival Arthritis Anti-Inflammatory Agents Non-Steroidal HIV Core Protein p24 Triterpenes Cell Line Rats Lethal Dose 50 Disease Models Animal Mice Adjuvants Immunologic Antibody Formation HIV-1 Plant Bark Animals Humans Stomach Ulcer Burns Betula |
| Zdroj: | Bioorganicheskaia khimiia. 28(6) |
| ISSN: | 0132-3423 |
| Popis: | The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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