Alternative anti-tuberculosis regimen including ofloxacin for the treatment of patients with hepatic injury
| Autor: | A, Szklo, F C Q, Mello, R L, Guerra, S E, Dorman, G R, Muzy-de-Souza, M B, Conde |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Ofloxacin Urban Population Antitubercular Agents Comorbidity Risk Assessment Severity of Illness Index Drug Administration Schedule Cohort Studies Liver Function Tests Recurrence Confidence Intervals Odds Ratio Humans Treatment Failure Tuberculosis Pulmonary Retrospective Studies Dose-Response Relationship Drug Hospitals Public Liver Diseases Mycobacterium tuberculosis Survival Rate Treatment Outcome Streptomycin Drug Therapy Combination Female Brazil Ethambutol Follow-Up Studies |
| Zdroj: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 11(7) |
| ISSN: | 1815-7920 |
| Popis: | Tuberculosis (TB) clinic of a university-based public hospital in Rio de Janeiro city, Brazil.To describe treatment outcomes for TB patients with liver injury who received a 12-month regimen of ethambutol (E, EMB) and ofloxacin (O, OFL), including streptomycin (S, SM) for the first 3 months (3SEO/9EO) under routine clinical care conditions.A retrospective study of a cohort of TB patients prescribed 3SEO/9EO was conducted over a 66-month period. Data were obtained by review of existing medical records. Primary outcomes assessed were cure, treatment failure, treatment default, TB relapse and death.Outcomes were assessed for 40 patients with hepatic injury who met study criteria. Twenty-three (58%) were male and 13 (33%) were human immunodeficiency virus seropositive. Thirty-four (85%) patients were cured. Three patients (7.5%) defaulted from treatment, and three other patients died (7.5%). There were no treatment failures or relapses during 2 years of follow-up. Clinically recognized drug toxicity occurred in five patients (12.5%), and in each case was attributed to SM.In this series of TB patients with serious liver injury, 3SEO/9EO was well-tolerated, and it was effective in 85% of patients when used under routine clinical care conditions. |
| Databáze: | OpenAIRE |
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