| Popis: |
From data on the molecular organization of transverse filament proteins of the synaptonemal complex (SC)--Zip1 in yeast and SCP1 in mammals--and on the width of the central SC space in these organisms and in Drosophila, the putative molecular structure and size of a transverse filament protein of the SC in Drosophila has been inferred. Using genetic and molecular databases and software from the Internet, we carried out in silico screening for a candidate gene for the Drosophila transverse filament protein. The search in the 250-bp region overlapping the locus of this gene (sections 88E-89B) and containing 78 predicted genes has revealed only one gene, CG17604, whose protein meets all requirements for the transverse filament protein of the SC. It was suggested that gene CG17604 is gene c(3)G. In this case, gene c(3)G must be localized in section 89A7-8 of the cytological map of Drosophila melanogaster. |
