| Autor: |
O, van Hecke, N, Torrance, L, Cochrane, J, Cavanagh, P T, Donnan, S, Padmanabhan, D J, Porteous, L, Hocking, B H, Smith |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
European journal of pain (London, England). 18(9) |
| ISSN: |
1532-2149 |
| Popis: |
Smokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the relationship between smoking, pain and depression in a large general population-based cohort (Generation Scotland: Scottish Family Health Study).Chronic pain measures (intensity, disability), self-reported smoking status and a history of major depressive disorder (MDD) were analysed. A multivariate analysis of covariance determined whether smoking status was associated with both pain measures and a history of depressive illness. Using a statistical mediation model any mediating effect of depression on the relationship between smoking and chronic pain was sought.Of all 24,024 participants, 30% (n = 7162) reported any chronic pain. Within this chronic pain group, 16% (n = 1158) had a history of MDD; 7108 had valid smoking data: 20% (n = 1408) were current smokers, 33% (n = 2351) former and 47% (n = 3349) never smokers. Current smokers demonstrated higher pain intensity and pain-related disability scores compared with former and non-smokers (p 0.001 for all analyses). From the mediation model, the effect on pain intensity decreased (p 0.001), indicating that the relationship between smoking and a history of depression contributes significantly to the effect of smoking on pain intensity. When applied to smoking-related pain disability, there was no mediation effect.In contrast to smokers treated in pain clinics, a history of MDD mediated the relationship between smoking and pain intensity, but not pain-related disability in smokers in the community. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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