Congenital abnormalities and pregestational diabetes mellitus in pregnancy

Autor: Y T, Chia, S, Chua, A C, Thai, L P, Kek, S S, Ratnam
Rok vydání: 1996
Předmět:
Zdroj: Singapore medical journal. 37(4)
ISSN: 0037-5675
Popis: Despite falling perinatal mortality rate, congenital malformation remains the major cause of mortality in infants of mothers with established diabetes. The perinatal mortality rate in this group of infants is 5 times the overall perinatal mortality rate in this hospital. It is well established that pre-pregnancy counselling and maintenance of euglycaemia during the periconception period are the keys to prevention of congenital malformation. We are able to offer pre-pregnancy counselling to 29% of our diabetic mothers who are diagnosed to have pregestational diabetes mellitus only after the 6 weeks postnatal oral glucose tolerance test. Even in the known established diabetes mellitus, 95% of the patients were first seen after the period of organogenesis (8 weeks). This could explain our high congenital malformation rate of 15.7%.
Databáze: OpenAIRE