Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A

Autor: Benjamin, Owen, Monica, de Gaetano, Andrew, Gaffney, Catherine, Godson, Patrick J, Guiry
Rok vydání: 2022
Předmět:
Zdroj: Organic letters. 24(32)
ISSN: 1523-7052
Popis: Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmetric synthesis of four BCP-containing synthetic lipoxin A
Databáze: OpenAIRE