| Autor: |
L A, McQuaid, J D, Leander, L G, Mendelsohn, E C, Smith, R R, Lawson, N R, Mason |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Research communications in chemical pathology and pharmacology. 77(2) |
| ISSN: |
0034-5164 |
| Popis: |
A series of imipramine analogs were tested for inhibition of [3H]-MK801 binding and for their ability to protect against NMDA-induced lethality in mice. The structure-activity relationship (SAR) for the inhibition of [3H]-MK801 binding found primary amines on short linkers to be optimum. For protection against NMDA lethality, compounds containing an unsaturated link to a cyclic amine were the most potent analogs tested. Possible explanations for the lack of correlation observed are briefly discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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