| Autor: |
Zubair H, Aghai, Ronald, Arevalo, Lorna, Lumicao, Martin, Lesser, Quihu, Shi, Ajey, Jain, Alfred N, Krauss, Peter A M, Auld, Hartmut M, Hanauske-Abel |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Biology of the neonate. 81(1) |
| ISSN: |
0006-3126 |
| Popis: |
Basement membranes, critical for vital organs like the lungs, consist of two interwoven homopolymers, one assembled by type IV collagens and one by laminins. We hypothesized their serum antigens C-IV and P1, respectively, to be global measures for the maturity of these organs. In 39 very low birth weight premature neonates (means: gestational age, 25.8 weeks; birth weight, 779 g) requiring intensive care, we analyzed these biomarkers during the first two months post partum. Median C-IV and P1 exceeded adult levels by one order of magnitude. The individuals with the lowest first week C-IV values (mean: 667 ng/ml) required significantly longer neonatal intensive care unit stays than those with the highest values (mean: 2,467 ng/ml), on average 109 vs. 80 days (p = 0.008) irrespective of gestational age. Patients diagnosed with bronchopulmonary dysplasia (BPD) at 36 weeks postconceptional age, already in their first week of life displayed C-IV levels lower than in controls, suggesting a defect in pulmonary basement membrane remodeling. This is the first identification by a matrix biomarker of a BPD-antecedent state. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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