| Autor: |
L R, Schopf, J, Erickson, L, Hayes, C, Chung, L, Lavigne, J, Sypek |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Parasite immunology. 23(2) |
| ISSN: |
0141-9838 |
| Popis: |
Changes in gene expression and cellular distribution in the lymph node and at the site of infection, the footpad, during Leishmania major infection and/or IL-12 administration were evaluated. Otherwise susceptible BALB/c mice given IL-12 are able to resolve infection. Interestingly, iNOS was not induced in the lymph node by IL-12, yet, nitric oxide is critical in the control of leishmaniasis. However, we observed an increase in iNOS at the lesion site in response to IL-12. These results reflect the importance of examining the primary site of infection. We observed no changes in inflammation at the lesion site; however, IL-12 promoted an early inflammatory response in the lymph nodes. IL-12 administration differentially affected both the local and systemic immune response to invading leishmanial parasites. IL-12 induced iNOS at the lesion site and an early granulomatous inflammation in the lymph node; therefore, we hypothesize that these are key events responsible for the resolution of disease in BALB/c mice treated with IL-12. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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