Platinum accumulation in the brain and alteration in the central regulation of cardiovascular and respiratory functions in oxaliplatin-treated rats
| Autor: | Ahmed A, Rahman, Vanesa, Stojanovska, Paul, Pilowsky, Kulmira, Nurgali |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Sympathetic Nervous System Antineoplastic Agents Splanchnic Nerves Baroreflex Chemoreceptor Cells Drug Administration Schedule Rats Cardiovascular Physiological Phenomena Oxaliplatin Rats Sprague-Dawley Random Allocation Blood Heart Rate Respiratory Physiological Phenomena Animals Tissue Distribution Platinum |
| Zdroj: | Pflugers Archiv : European journal of physiology. 473(1) |
| ISSN: | 1432-2013 |
| Popis: | Oxaliplatin is a platinum-based alkylating chemotherapeutic agent used for cancer treatment. Neurotoxicity is one of its major adverse effects that often demands dose limitation. However, the effects of chronic oxaliplatin on the toxicity of the autonomic nervous system regulating cardiorespiratory function and adaptive reflexes are unknown. Male Sprague Dawley rats were treated with intraperitoneal oxaliplatin (3 mg kg |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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