[Rhythm of expression of BCL-2 protein of MA13/C mammaryadenocarcinoma bearing-mice]
| Autor: | Teresa G, Granda, Elisabeth, Filipski, P, Vrignaud, M C, Bissery, Francis, Lévi |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 2003 |
| Předmět: |
Chronotherapy
Male Mice Inbred C3H Mammary Neoplasms Experimental Docetaxel Adenocarcinoma Antineoplastic Agents Phytogenic Circadian Rhythm Genes bcl-2 Neoplasm Proteins Gene Expression Regulation Neoplastic Mice Proto-Oncogene Proteins c-bcl-2 Bone Marrow Animals Taxoids Bone Marrow Diseases Neoplasm Transplantation |
| Zdroj: | Pathologie-biologie. 51(4) |
| ISSN: | 0369-8114 |
| Popis: | We previously demonstrated a circadian rhythm in response to docetaxel chemotherapy in C3H/HeN mice bearing MA13/C mammary adenocarcinoma. We investigated the relation between this rhythm and the expression of BCL-2 in bone marrow and in tumor tissues. A circadian rhythm characterized BCL-2 expression in the bone marrow, which was hardly modified in tumor-bearing animals. BCL-2 acrophase coincided with the time of highest docetaxel tolerability and efficacy in this model. This suggests that BCL-2 protects the bone marrow from the drug toxicity, especially during the light phase. |
| Databáze: | OpenAIRE |
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