Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas
| Autor: | M, Volm, R, Koomagi, M, Kaufmann, J, Mattern, G, Stammler |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Ovarian Neoplasms Adolescent Microcirculation Carcinoma Genes myc Genes erbB-1 Middle Aged Immunohistochemistry Proto-Oncogene Mas ErbB Receptors Genes jun Drug Resistance Neoplasm Proto-Oncogene Proteins Humans Female HSP70 Heat-Shock Proteins ATP Binding Cassette Transporter Subfamily B Member 1 Neoplasm Metastasis Aged Glutathione Transferase |
| Zdroj: | Clinicalexperimental metastasis. 14(3) |
| ISSN: | 0262-0898 |
| Popis: | Relationships between the incidence of metastatic spread and microvessel density, expression of proto-oncogene products, or expression of resistance-related proteins were investigated in human ovarian carcinomas by immunohistochemistry. Ovarian carcinomas with a high microvessel density showed a significantly increased formation of metastases (P = 0.005). Tumors with positive immunoreactivity of c-jun and c-myc products had a higher metastatic spread; however, these results were not statistically significant. A marginally significant correlation existed between the expression of erbB1 (EGFR) and metastatic spread (P = 0.05). No significant relationship was found between the expression of the resistance-related proteins P-glycoprotein or glutathione S-transferase-pi and the incidence of metastases. Furthermore, no correlation was detected between expression of the heat shock protein 70 and the occurrence of metastases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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