[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000]
Autor: | N V, Miakova, R, Hartmann, A E, Rudneva, N M, Trubina, L G, Fechina, A M, Timakov, A V, Shamardina, V V, Lebedev, S R, Varfolomeeva, S D, Dudkin, Z M, Dyshlevaia, V N, Timofeeva, A G, Rumiantsev, H, Henze, A I, Karachunskiĭ |
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Rok vydání: | 2002 |
Předmět: |
Male
Antimetabolites Antineoplastic Time Factors Adolescent Antineoplastic Agents Hormonal Antineoplastic Agents Moscow Dexamethasone Russia Risk Factors Antineoplastic Combined Chemotherapy Protocols Asparaginase Humans Child Mercaptopurine Daunorubicin Remission Induction Cytarabine Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma Antineoplastic Agents Phytogenic Survival Analysis Methotrexate Vincristine Child Preschool Data Interpretation Statistical Female Follow-Up Studies |
Zdroj: | Voprosy onkologii. 48(3) |
ISSN: | 0507-3758 |
Popis: | The report deals with the results of application of an original protocol--the Berlin-Moscow-91 (BM-91)--for the treatment of acute lymphoblastic leukemia (ALL) in children. The researchers' major concern was to improve survival and cut down side-effects incidence as well as to prevent and successfully manage occult neuroleukemia as a potential source of relapse. Patients aged 5 months-15 years received the BM-91 and ALL BFM-90m treatment first at one clinic and later at several centers. Out of 852 children with primary diagnosis of ALL admitted to Russian hematological hospitals (March 2, 1991-November 3, 2000), 687 were included into the study; 329 received the MB-91 protocol. Nine-year recurrence-free survival was 73% while overall survival--80%. Toxic side-effects after L-asparaginase were reported in 27 (7.9%). It is concluded that good results in childhood ALL treatment can be achieved without resorting to high-dosage chemotherapy and radiation in most cases. |
Databáze: | OpenAIRE |
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