| Autor: |
Ming, Tong, Xiquan, Yan, Yu, Jiang, Zhaoxia, Jin, Shengjiao, Zhu, Lianhong, Zou, Yanjuan, Liu, Qing, Zheng, Guoqiang, Chen, Ruifeng, Gu, Zhilan, Zhou, Xiaotong, Han, Jiangming, He, Siqing, Yin, Changchun, Ma, Wen, Xiao, Yong, Zeng, Fang, Chen, Yimin, Zhu |
| Rok vydání: |
2021 |
| Zdroj: |
Mediterranean journal of hematology and infectious diseases. 14(1) |
| ISSN: |
2035-3006 |
| Popis: |
COVID-19 is characterized by endothelial dysfunction and is presumed to have long-term cardiovascular sequelae. In this cross-sectional study, we aimed to explore the serum levels of endothelial biomarkers in patients who recovered from COVID-19 one year after hospital discharge.In this clinical follow-up study, 345 COVID-19 survivors from Huanggang, Hubei, and 119 age and gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram and Doppler ultrasound of lower extremities, routine blood tests, biochemical and immunological tests, serum soluble vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine were measured by enzyme-linked immunosorbent assays (ELISA).At one year after discharge, 39% of recovers possessed post-COVID syndromes, while a few had abnormal electrocardiogram manifestations, and no deep vein thrombosis was detected in all screened survivors. There were no significant differences in circulatory inflammatory markers (leukocytes, neutrophils, lymphocytes, C-reactive protein and interleukin-6), alanine aminotransferase, estimated glomerular filtration rate, glucose, triglycerides, total cholesterol and D-dimer observed among healthy controls with previously mild or severe infected. Furthermore, serum levels of VCAM-1, ICAM-1, P-selectin, and fractalkine do not significantly differ between survivors and healthy controls.SARS-CoV-2 infection may not impose a higher risk of developing long-term cardiovascular events, even for those recovering from severe illness. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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