Evaluation of Nanotargeted
| Autor: | Si-Yen, Liu, Sheng-Nan, Lo, Wan-Chi, Lee, Wei-Chuan, Hsu, Te-Wei, Lee, Chih-Hsien, Chang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Tomography
Emission-Computed Single-Photon 111In-cyclic RGDfK-liposome Mice Inbred BALB C Phagocytes Nanotargeted liposome Indium Radioisotopes X-Ray Microtomography αVβ3 integrin Integrin alphaVbeta3 Peptides Cyclic Article Mice RAW 264.7 Cells Cell Line Tumor Liposomes Cell Adhesion Animals Humans Female Peptides Reactive Oxygen Species Melanoma Neoplasm Transplantation |
| Zdroj: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Nanotargeted liposomes may be modified with targeting peptide on the surface of a prepared liposome to endow specificity and elevate targeting efficiency. The aim of this study was to develop a radioactive targeted nanoparticle, the 111In-cyclic RGDfK-liposome, and its advantage of recognizing the αVβ3 integrin was examined. The cyclic RGDfK modified liposomes were demonstrated the ability to bind the αVβ3 integrin expressed on the surface of human melanoma cell in vitro and in vivo. The effects of the cyclic RGDfK-liposome on the functioning of phagocytes was also examined, showing no considerable negative effects on the engulfment of bacteria and the generation of reactive oxygen species. Based upon these findings, the cyclic RGDfK- liposome is said to be a promising agent for tumor imaging. |
| Databáze: | OpenAIRE |
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