| Autor: |
O M, Laudanno, J M, Esnarriaga, J A, Cesolari, C B, Maglione, L J, Aramberry, J S, Sambrano, G, Piombo, L, Rista |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Medicina. 60(2) |
| ISSN: |
0025-7680 |
| Popis: |
In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied. Celecoxib was given each 12 hs orally and subcutaneously during 5 days and gastrointestinal lesions were not found; in contrast, Celecoxib given after indomethacin aggravated antrum gastric ulcers (p0.001); intestinal massive necrosis and death were observed in all the rats. We conclude that Celecoxib does not induce gastrointestinal lesions in healthy mucosa; in contrast, Celecoxib amplifies the gastrointestinal lesions induced by indomethacin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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