Understanding breast cancer heterogeneity through non-genetic heterogeneity

Autor:	Neda, Barzgar Barough, Fakhrosadat, Sajjadian, Nazila, Jalilzadeh, Hajar, Shafaei, Kobra, Velaei
Rok vydání:	2020
Předmět:	Genetic Heterogeneity Phenotype Neoplastic Stem Cells Tumor Microenvironment Humans Breast Neoplasms Female Cell Division Signal Transduction
Zdroj:	Breast cancer (Tokyo, Japan). 28(4)
ISSN:	1880-4233
Popis:	Intricacy in treatment and diagnosis of breast cancer has been an obstacle due to genotype and phenotype heterogeneity. Understanding of non-genetic heterogeneity mechanisms along with considering role of genetic heterogeneity may fill the gaps in landscape painting of heterogeneity. The main factors contribute to non-genetic heterogeneity including: transcriptional pulsing/bursting or discontinuous transcriptions, stochastic partitioning of components at cell division and various signal transduction from tumor ecosystem. Throughout this review, we desired to provide a conceptual framework focused on non-genetic heterogeneity, which has been intended to offer insight into prediction, diagnosis and treatment of breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3b1dc8b04aa679b574f89f5f763c961d https://pubmed.ncbi.nlm.nih.gov/33723745 Zobrazit plný text záznamu Full text from SpringerLink