Comparative in vitro evaluation of dequalinium B, a new boron carrier for neutron capture therapy (NCT)
| Autor: | D M, Adams, W, Ji, R F, Barth, W, Tjarks |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Drug Carriers
Brain Neoplasms Pyridines Antineoplastic Agents Boron Neutron Capture Therapy Epithelial Cells Glioma KB Cells Rats Inbred F344 Cell Line Rats Thiazoles Onium Compounds Organophosphorus Compounds Dequalinium Chlorocebus aethiops Tumor Cells Cultured Animals Humans Rhodamine 123 Boranes |
| Zdroj: | Anticancer research. 20(5B) |
| ISSN: | 0250-7005 |
| Popis: | A boronated derivative of dequalinium, a delocalized lipophilic cation (DLC), was synthesized as a potential boron carrier for the selective targeting of mitochondria in malignant versus benign cells for boron neutron capture therapy (BNCT), a binary modality for the treatment of cancer. This agent, designated DEQ-B, was taken up and retained in vitro in the KB, F98, and C6 tumor cell lines but not in the normal epithelial cell line CV1. DEQ-B was also less toxic in the latter cell line at lower exposure concentrations The uptake, retention, and toxicity profiles of DEQ-B are comparable to those of the non-boronated DLCs, dequalinium, MKT 077, RH 123, and tetraphenylphosphonium chloride. Our results suggest that the synthesis and further evaluation of boronated DLCs as potential delivery agents for BNCT is warranted. |
| Databáze: | OpenAIRE |
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