The Nuclear Receptor Cofactor RIP140 is Required for the Regulation of Hepatic Lipid and Glucose Metabolism by LXR
| Autor: | Herzog, Birger, Hallberg, Magnus, Seth, Asha, Woods, Angela, White, Roger, Parker, Malcolm G. |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Mice
Knockout Gluconeogenesis food and beverages Nuclear Proteins Receptors Cytoplasmic and Nuclear Lipid Metabolism Orphan Nuclear Receptors digestive system Article Nuclear Receptor Interacting Protein 1 DNA-Binding Proteins Mice Glucose Gene Expression Regulation Liver polycyclic compounds Hepatocytes Animals Humans lipids (amino acids peptides and proteins) Promoter Regions Genetic Phosphoenolpyruvate Carboxykinase (ATP) Adaptor Proteins Signal Transducing Liver X Receptors Plasmids |
| Popis: | The liver X receptors (LXRs) are nuclear receptors that play important roles in the regulation of lipid metabolism. In this study, we demonstrate that receptor-interacting protein 140 (RIP140) is a cofactor for LXR in liver. Analysis of RIP140 null mice and hepatocytes depleted of RIP140 indicate that the cofactor is essential for the ability of LXR to activate the expression of a set of genes required for lipogenesis. Furthermore we demonstrate that RIP140 is required for the ability of LXR to repress the expression of the phosphoenolpyruvate carboxykinase gene in Fao cells and mice. Thus, we conclude that the function of RIP140 as a cofactor for LXR in liver varies according to the target genes and metabolic process, serving as a coactivator in lipogenesis but as a corepressor in gluconeogenesis. |
| Databáze: | OpenAIRE |
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