| Autor: |
Yoav, Siegler, N, Justman, G, Bachar, R, Lauterbach, Y, Zipori, N, Khatib, Z, Weiner, D, Vitner |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Archives of gynecology and obstetrics. 306(5) |
| ISSN: |
1432-0711 |
| Popis: |
We assessed the association between a short antenatal corticosteroid administration-to-birth interval and neonatal outcome.A retrospective study was conducted between 2010 and 2020. Eligible cases were singleton preterm live-born neonates born between 24-0/7 and 33-6/7 weeks of gestation and were initiated an ACS course of betamethasone. We divided the first 48 h following the first ACS administration to four time intervals and compared each time interval to those born more than 48 h following ACS administration. The primary outcome was a composite of adverse neonatal outcome, including neonatal mortality or any major neonatal morbidity.A total of 200 women gave birth less than 48 h from receiving the first betamethasone injection, and 172 women gave birth within 2-7 days (48-168 h) from ACS administration. Composite adverse neonatal outcome was higher for neonates born less than 12 h from initial ACS administration compared to neonates born 2-7 days from the first betamethasone injection (55.45% vs. 29.07%, OR 3.45 95% CI [2.02-5.89], p value 0.0001). However, there was no difference in composite adverse neonatal outcomes between neonates born 12-48 h following ACS administration and those born after 2-7 days. That was also true after adjusting for confounders.12-24 h following ACS administration may be sufficient in reducing the same risk of neonatal morbidities as 48 h following ACS administration. It may raise the question regarding the utility of the second dose of ACS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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