| Autor: |
I M, Veshkurtseva, E A, Ortenberg, V G, Bychkova, A I, Zhikhareva, M K, Chabanova |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 58(6) |
| ISSN: |
0869-2092 |
| Popis: |
At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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