Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α
| Autor: | Maki, Fujimoto, Hitoshi, Higuchi, Yuka, Honda-Wakasugi, Saki, Miyake, Yukiko, Nishioka, Akiko, Yabuki-Kawase, Shigeru, Maeda, Takuya, Miyawaki |
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| Rok vydání: | 2020 |
| Předmět: |
Inflammation
Lipopolysaccharides Interleukin-6 Prostaglandin D2 Tumor Necrosis Factor-alpha Macrophages Anti-Inflammatory Agents Dinoprostone PPAR gamma Mice RAW 264.7 Cells Cyclooxygenase 2 Adrenergic alpha-2 Receptor Agonists Animals Receptors Adrenergic beta-2 Dexmedetomidine Protein Binding Signal Transduction |
| Zdroj: | European journal of pharmacology. 892 |
| ISSN: | 1879-0712 |
| Popis: | Over the past decade, dexmedetomidine (DEX) has been found to possess an anti-inflammatory effect. However, the local anti-inflammatory mechanism of DEX has not been fully clarified. Some intracellular inflammatory pathways lead to negative feedback during the inflammatory process. The cyclooxygenase (COX) cascade synthesizes prostaglandins (PGs) and plays a key role in inflammation, but is known to also have anti-inflammatory properties through an alternative route of a PGD |
| Databáze: | OpenAIRE |
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