[Polyunsaturated fatty acids omega-3 as modulators of intracellular signaling pathways]

Autor:	Monika K, Duda
Rok vydání:	2012
Předmět:	Cardiotonic Agents Docosahexaenoic Acids Eicosapentaenoic Acid Cardiovascular Diseases Cell Membrane Fatty Acids Omega-3 Intracellular Signaling Peptides and Proteins Animals Humans Receptors Cytoplasmic and Nuclear Ion Channels Signal Transduction Transcription Factors
Zdroj:	Postepy biochemii. 58(2)
ISSN:	0032-5422
Popis:	Polyunsaturated fatty acids omega-3 (PUFA omega-3), in particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact signaling pathways involved in the development of cardiovascular diseases. PUFA omega-3 affect a myriad of molecular pathways, including alteration physical and chemical properties of membrane microdomains, modulation of membrane receptors and channels, regulation of gene expression via nuclear receptors and transcription factors and changes in eicosanoid clasess' profiles and conversion of EPA and DHA to proresolving mediators. This review summarizes our current knowledge regarding the mechanism of cardioprotective action of PUFA omega-3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3a8839ddface65208a93f30658fd4616 https://pubmed.ncbi.nlm.nih.gov/23214138 Zobrazit plný text záznamu