| Autor: |
M, Rubio Caballero, A, Nogués Biau, M, Falguera Sacrest, T, Puig Gatnau, L, Lorente |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Anales de medicina interna (Madrid, Spain : 1984). 15(12) |
| ISSN: |
0212-7199 |
| Popis: |
To analyse plasma p24 antigen as a marker of survival in a cohort of HIV-infected patients whose time of seroconversion is unknown.Prospective cohort study.AIDS Unit in a teaching hospital.251 patients were studied, most on antiretroviral therapy. Mean initial CD4 cell counts were 376 x 106/ 1 (range: 0.8-1350). 51 cases had been diagnosed previously with AIDS.Analysis of survival, according to initial plasma p24 antigen was performed by Kaplan-Meier test. Relative risks were calculated by Cox's proportional hazards model.During a follow-up period of 24 months, 46 patients died. Relative risk (RR) of death related to the group with p24 antigen =40 pg/ml was 3.32 when p24 antigen40 pg/ml (p = 0.0001). CD4+ cell levels adjusting, the result was 2.47 (CI 95% 1.37-4.46) (p = 0.0027).Plasma levels of p24 antigen is useful as a marker of the risk of death and it behaves as a independent prognostic marker in our patients. P24 antigen =40 pg/ml is associated with a better prognosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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