Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P

Autor:	Haruto, Kurata, Kensuke, Kusumi, Kazuhiro, Otsuki, Ryo, Suzuki, Masakuni, Kurono, Takaki, Komiya, Hiroshi, Hagiya, Hirotaka, Mizuno, Hiroki, Shioya, Takeji, Ono, Yuka, Takada, Tatsuo, Maeda, Norikazu, Matsunaga, Tetsu, Kondo, Sachiko, Tominaga, Ken-Ici, Nunoya, Hidekazu, Kiyoshi, Masaharu, Komeno, Shinji, Nakade, Hiromu, Habashita
Rok vydání:	2017
Předmět:	Male Mice Inbred BALB C Administration Oral CHO Cells Naphthalenes Autoimmune Diseases Rats Sprague-Dawley Macaca fascicularis Mice Receptors Lysosphingolipid Cricetulus Rats Inbred Lew Animals Azetidines Humans Female Lymphocytes
Zdroj:	Journal of medicinal chemistry. 60(23)
ISSN:	1520-4804
Popis:	The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::39f84e90dba8221686c7c9d410b02f32 https://pubmed.ncbi.nlm.nih.gov/29120624 Zobrazit plný text záznamu