| Autor: |
Alkis J, Psaltis, Rodney J, Schlosser, James R, Yawn, Oswaldo, Henriquez, Jennifer K, Mulligan |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
International forum of allergyrhinology. 3(8) |
| ISSN: |
2042-6984 |
| Popis: |
Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients.Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single-cell suspension flow cytometry these samples were analyzed for overall and stage-specific B and plasma cell percentages.Both atopic and nonatopic CRSwNP patients showed an increase in local numbers of naive, active, and memory B cells compared to controls. CRSsNP patients only showed local elevations of naive B cells. Plasma cells were only significantly elevated in the sinus tissue of atopic CRSwNP patients. These local tissue increases did not correlate with increased numbers of circulating B cells.This study provides further evidence of an important role of B cells in CRSwNP patients. The local increase appears to be independent of a systemic response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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