| Autor: |
T G, Pankova, T V, Maĭer, T M, Igonina, S A, Rabinovich, E N, Morozov |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Meditsinskaia parazitologiia i parazitarnye bolezni. (4) |
| ISSN: |
0025-8326 |
| Popis: |
This comparative study was made to examine chroloquine inhibition of C14-hypoxanthine incorporation (preferably nucleic acid precursor for plasmodium) in the short-living red blood cell cultures in mice infected with P. berghei strains differently sensitive to the agent 24 hours after incubation. These included 1) chloroquine-sensitive H strain; 2) LNK-65 strain having a spontaneously 2-3-fold decreased sensitivity to the agent; 3) strain LNK-65 ChR selected for high resistance to chloroquine. IC50 (chloroquine concentrations that ensure 50% inhibition of the incorporation of nucleic acid precursor into the cells of the parasite) was estimated for 3 P. berghei strains that were differently sensitive to chloroquine. These in vitro values adequately reflect the sensitivity of these strains to the agent in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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