Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples

Autor:	R, Muresu, A, Cossu, A M, Scarpa, E V, Volpi, P C, Rocca, A, Pintus, M G, Tibiletti, F, Tanda, M, Pirastu, G, Massarelli
Rok vydání:	1998
Předmět:	Adult Genetic Markers Paraffin Embedding Chromosomes Human Pair 10 Middle Aged Aneuploidy Endometrial Neoplasms Carcinoma Adenosquamous Chromosomes Human Pair 1 Humans Female Carcinoma Endometrioid In Situ Hybridization Fluorescence Aged Retrospective Studies
Zdroj:	Cancer genetics and cytogenetics. 107(1)
ISSN:	0165-4608
Popis:	Retrospective analysis of chromosomal changes in endometrial carcinoma was performed by fluorescence in situ hybridization on free nuclei isolated from formalin-fixed paraffin-embedded tissue. We examined 23 archival samples for numerical aberrations of chromosomes 1 and 10 with the use of specific DNA probes for the pericentromeric and centromeric regions of these two chromosomes. Numerical aberrations of chromosomes 1 and 10 were detected in 39% of the case analyzed, and the frequency of trisomy 10 tended to increase as the histological grade worsened. Our findings confirm the association of cytogenetic anomalies involving chromosomes 1 and 10 with endometrial carcinoma, as reported by other studies, and suggest that changes in centromere 10 copy number may correlate with the degree of tumor differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::394813d0d312bed53575e84dea86828c https://pubmed.ncbi.nlm.nih.gov/9809032 Zobrazit plný text záznamu Full Text from ScienceDirect