Alcoholic Extract of
| Autor: | Navneet Kumar, Yadav, Rakesh Kumar, Arya, Kapil, Dev, Chetan, Sharma, Zakir, Hossain, Sanjeev, Meena, K R, Arya, J R, Gayen, Dipak, Datta, R K, Singh |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Membrane Potential Mitochondrial Ethanol Plant Extracts Apoptosis Eclipta Antineoplastic Agents Phytogenic Antioxidants Rats HEK293 Cells Neoplasms Chlorocebus aethiops MCF-7 Cells Animals Humans Female Lipid Peroxidation Reactive Oxygen Species Vero Cells Cells Cultured HeLa Cells Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 |
| Popis: | As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control. We have also evaluated its effect on different in vivo toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer. |
| Databáze: | OpenAIRE |
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