SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CERTAIN MESOIONIC SYDNONE COMPOUNDS CONTAINING CHALCONE MOIETY

Autor:	Deshpande, Shreenivas R., Pai, K. Vasantakumar
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	sydnone Synthesis antibacterial chalcone heterocyclic compounds Original Article anti-inflammatory
Zdroj:	Journal of Basic and Clinical Pharmacy
ISSN:	0976-0113 0976-0105
Popis:	In order to have antibacterial, analgesic and anti-inflammatory activity in the same molecule, 4-[1-oxo-3- (substituted aryl)-2-propenyl]-3-(4-chlorophenyl) sydnones were synthesized by condensing 4-acetyl-3-(4-chlorophenyl)sydnone with various substituted aryl aldehydes and characterized by spectral studies; 4-acetyl-3-(4-chlorophenyl)sydnone itself, was prepared by acetylation of 3-(4-chlorophenyl) sydnone. The newly synthesized compounds were evaluated for antibacterial and anti-inflammatory activities by cup plate and carrageenan induced rat paw edema methods respectively. Some of the compounds showed promising antibacterial and anti-inflammatory activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::38f752b609e2e04abf3f08c3e332b5ae http://europepmc.org/articles/PMC3979191 Zobrazit plný text záznamu