Antibodies to meningococcus polysaccharides in nonspecific gamma-globulins from different regions of the world

Autor: A A, Demina, I M, Samsonova, M T, Fayet, J, Béranger, N, Gibilin, R, Plan, R, Triau
Rok vydání: 1983
Předmět:
Zdroj: Journal of hygiene, epidemiology, microbiology, and immunology. 27(4)
ISSN: 0022-1732
Popis: Seventy-one batches of nonspecific gamma-globulin obtained from France, USSR and Mongolia were studied for presence of specific antibody to group A and C meningococcus polysaccharide. Specific activity was tested by two methods: radioimmunoassay (Lyon) and reaction of passive haemagglutination inhibition (Moscow). Antibodies were detected in all the gamma-globulin batches tested, in some of them at high titres. The summary results indicated that approximately equal levels of specific A antibodies were present in preparations obtained from the different regions of the world. Antibodies to group C polysaccharide showed considerable variation in level from selection country to country; the highest level of C antibodies was in gamma-globulin from France. The authors feel entitled by the results to recommend testing of nonspecific gamma-globulin, selection of batches with a high level of specific antimeningococcus antibodies, and their judicious use.
Databáze: OpenAIRE