Forced running-induced rhabdomyolysis in the Sprague-Dawley rat: towards a rodent model of capture myopathy

Autor:	Crystal, Lubbe, Brian H, Harvey, Francois P, Viljoen, Leith, Meyer, De Wet, Wolmarans
Rok vydání:	2021
Předmět:	Male Rats Sprague-Dawley Disease Models Animal Muscular Diseases Exercise Test Animals Female Rats Running
Zdroj:	Veterinary research communications. 45(4)
ISSN:	1573-7446
Popis:	Capture myopathy (CM) is a metabolic disease associated with mortality in mass boma captured (MBC) wildlife. The condition is induced by the forced pursuit, capturing, and restraint of wild animals, although its causal biology remains to be confirmed. A core feature of MBC-CM is rhabdomyolysis, which is associated with myoglobinuria and hyperthermia. Towards developing a translational model of CM-associated rhabdomyolysis, we investigated forced treadmill running to induce physical exhaustion and trigger rhabdomyolysis in Sprague Dawley (SD) rats. Twenty-four (24) SD rats (12 per sex) were subjected to treadmill habituation in a speed-tiered approach. Forty-eight hours after the last habituation session, one strenuous exercise (SE) session was performed at 75% of the theoretical VO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::38e7b4e950949fb66e81187c2f61bcc4 https://pubmed.ncbi.nlm.nih.gov/34570329 Zobrazit plný text záznamu Full text from SpringerLink